Document Detail


Effects of training on metabolic responses and performance capacity in Streptococcus pneumoniae infected rats.
MedLine Citation:
PMID:  2056899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
These experiments were designed to study whether endurance training prior to Streptococcus pneumoniae infection in rats (N = 15 in each group) alters lethality, performance capacity, and related energy metabolism. A 5-d.wk-1, 4-wk-long pre-infection training program with gradually increasing swim time caused no protection from lethality (48% at 72 h post-inoculation), but performance capacity increased by 68% (P less than 0.01). The catabolic responses as evidenced by changes in insulin and glucagon levels were less pronounced. Mobilization of free fatty acids increased twofold (P less than 0.01), and improved ketonemic adaptation (47%, P less than 0.01) occurred with concomitant saved carcass, liver, and skeletal muscle glycogen contents (P less than 0.01). This shift from carbohydrate toward fat metabolism during exercise as a result of training was also reflected by 21% lower (P less than 0.01) blood lactate levels. It was concluded that the improved metabolic status, characterizing the trained as compared with the untrained host, is partly preserved during ongoing acute gram-positive bacterial infection.
Authors:
N G Ilbäck; G Friman; D J Crawford; H A Neufeld
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  23     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-29     Completed Date:  1991-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM; S    
Affiliation:
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature
Carbohydrate Metabolism*
Fatigue / metabolism
Fatty Acids / blood
Glucose / metabolism
Glycogen / metabolism
Ketone Bodies / blood
Lactates / blood,  metabolism
Lactic Acid
Liver / metabolism
Male
Muscles / metabolism
Myocardium / metabolism
Physical Conditioning, Animal*
Pneumococcal Infections / metabolism*
Rats
Rats, Inbred F344
Zinc / blood
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Ketone Bodies; 0/Lactates; 50-21-5/Lactic Acid; 50-99-7/Glucose; 7440-66-6/Zinc; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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