Document Detail

Effects of training and immobilization on VO2 and DO2 in dog gastrocnemius muscle in situ.
MedLine Citation:
PMID:  8514685     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of exercise training and immobilization on peak O2 uptake (VO2) and effective O2 diffusive conductance (DO2) in skeletal muscle, three groups of purpose-bred hounds [control (C), exercise trained (E), and immobilized (I)] were studied. Group E exercised on a treadmill 1 h/day, 5 days/wk for 8 wk, while groups C and I were cage confined for 8 wk, with group I undergoing left hindlimb immobilization for the last 3 wk. Thereafter, each dog's left gastrocnemius was surgically isolated, pump perfused, and electrically stimulated to elicit peak VO2 in situ at three levels of arterial oxygenation. O2 delivery [(arterial O2 concentration x muscle blood flow)/100 g muscle] was kept constant among the three groups at each level of arterial oxygenation. Compared with group C, peak VO2/100 g muscle was 38, 33, and 19% greater and DO2/100 g muscle was 71, 75, and 68% greater during normoxia, moderate hypoxia, and severe hypoxia, respectively, in group E (P < 0.02), whereas no differences from control were found in group I. We conclude that O2 delivery is not the unique determinant of peak VO2 and that exercise training improves the functional blood-tissue gas exchange properties of the muscle itself. Immobilization sufficient to reduce muscle weight by 31% and citrate synthase activity by 68% has no effect on peak VO2/100 g muscle or DO2/100 g muscle.
D E Bebout; M C Hogan; S C Hempleman; P D Wagner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  74     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1697-703     Citation Subset:  IM; S    
Department of Medicine, School of Medicine, University of California, San Diego, La Jolla 92093-0623.
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MeSH Terms
Acid-Base Equilibrium
Adaptation, Physiological
Anoxia / metabolism
Citrate (si)-Synthase / metabolism
Immobilization / adverse effects,  physiology*
Muscle Contraction / physiology
Muscles / blood supply,  metabolism*
Muscular Atrophy / etiology,  metabolism
Oxygen / blood,  metabolism*
Physical Conditioning, Animal*
Physical Endurance / physiology
Grant Support
Reg. No./Substance:
7782-44-7/Oxygen; EC (si)-Synthase

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