Document Detail

Effects of training on the distribution of cardiac output in patients with coronary artery disease.
MedLine Citation:
PMID:  11993304     Owner:  NLM     Status:  MEDLINE    
In nine patients with coronary artery disease, cardiac output distribution was evaluated at rest and during exercise by measurement of cardiac output and regional blood flow parameters (hepatic and muscle blood flow). In seven patients repeated values were obtained after a physical training program of 4 to 10 weeks' duration. After training, cardiac output was reduced at moderate work loads (13.1%) causing a change of the relation between oxygen uptake and cardiac output from hyperkinetic to normal. During heavy exercise the cardiac output was increased (5.5%) after training. Similar changes were observed in muscle blood flow, which was reduced at submaximal loads (14.9%) and increased at maximal (8.6%). Hepatic blood flow showed in contrast a less pronounced reduction at both work loads after training (difference, 7.2%). These effects of training could be explained as peripheral regulatory alterations without implying primary improvement in myocardial performance. They are consistent with the view that local changes in the trained muscles are important for the reduction in myocardial pressure-work caused by physical conditioning.
J P Clausen; J Trap-Jensen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  42     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  1970 Oct 
Date Detail:
Created Date:  2002-05-07     Completed Date:  2002-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-24     Citation Subset:  AIM; IM    
Department of Clinical Physiology, Department of Medicine C, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Cardiac Output
Coronary Artery Disease / blood,  physiopathology*
Exercise Test
Liver / blood supply
Middle Aged
Muscle, Skeletal / blood supply
Oxygen Consumption
Regional Blood Flow

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