| Effects of traditional Chinese formulations on rat carotid artery injured by balloon endothelial denudation. | |
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MedLine Citation:
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PMID: 12856859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the inhibitory effects of traditional Chinese formulations (TCFs: Kampo formulation in Japanese) on intimal thickening of the carotid artery injured by balloon endothelial denudation in rats. Among the eight TCFs examined oren-gedoku-to (huanglian-jiedu-tang in Chinese), choto-san (diao-teng-san), saiko-ka-ryukotsu-borei-to (chaihujia-longgu-muli-tang) and dai-joki-to (da-cheng-qi-tang) significantly inhibited the intimal thickening 7 days after denudation. These four TCFs also inhibited proliferation of vascular smooth muscle cells (VSMC), which may play a central role in the development of restenosis after balloon endothelial denudation. The present results suggest that further evaluation of these four TCFs as inhibitors of VSMC proliferation to prevent arteriosclerosis is warranted. |
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Authors:
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Hwa-Jin Chung; Dong-Wook Kim; Ikuro Maruyama; Tadato Tani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of Chinese medicine Volume: 31 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-07-14 Completed Date: 2003-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: United States |
Other Details:
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Languages: eng Pagination: 201-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthranilic Acids / therapeutic use Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Balloon Dilatation Body Weight / physiology Carotid Artery Injuries / drug therapy* Carotid Stenosis / drug therapy, pathology Cell Division / drug effects Drugs, Chinese Herbal / therapeutic use* Endothelium, Vascular / injuries* Indicators and Reagents Luminol / diagnostic use Male Muscle, Smooth, Vascular / cytology, drug effects Proliferating Cell Nuclear Antigen Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Anthranilic Acids; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drugs, Chinese Herbal; 0/Indicators and Reagents; 0/Proliferating Cell Nuclear Antigen; 521-31-3/Luminol; 53902-12-8/tranilast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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