Document Detail

Effects of tracheal instillation of natural surfactant in premature lambs. I. Clinical and autopsy findings.
MedLine Citation:
PMID:  581094     Owner:  NLM     Status:  MEDLINE    
Ten pairs of twin lambs 118--122 days of gestation were given either natural surfactant or diluent endotracheally before the first breath. By using the premature twin lamb model, we have been able to show that instillation of natural surfactant produced 100% survival for the duration of the study period (2 hr); stable blood gases on room air; lungs that became increasingly compliant while on the respirator; generally well aerated lungs at autopsy; good lung pressure-volume relationships; normal lung surface tension measurements; and histologic evidence of good alveolar expansion with large amounts of free intraluminal phospholipid, no epithelial damage, and no hyaline membranes. It is concluded that tracheal instillation of natural surfactant into the premature lamb protects the lungs from developing many features characteristic of the respiratory distress syndrome.
F H Adams; B Towers; A B Osher; M Ikegami; T Fujiwara; M Nozaki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  12     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  841-8     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal
Hyaline Membrane Disease / prevention & control
Infant, Newborn
Infant, Premature
Lung / drug effects*,  pathology
Prenatal Care
Pulmonary Surfactants / pharmacology*,  therapeutic use
Respiratory Distress Syndrome, Newborn / prevention & control*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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