Document Detail


Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome.
MedLine Citation:
PMID:  14551884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxic shock syndrome (TSS) may be mediated by superantigen-activated T cells, a theory we tested in rabbits, which are more susceptible to the lethal effects of superantigens, such as TSS toxin-1 (TSST-1), than are mice. Rabbits exposed to 10 cGy of total body irradiation exhibited T cell deficiency, with profound depletion of splenic lymphocytes and circulating CD4(+) lymphocytes, as well as an inability to manifest delayed-type hypersensitivity. Nevertheless, these rabbits remained completely susceptible to TSST-1, indicating that TSS can occur in the setting of marked immunosuppression.
Authors:
Martin M Dinges; Dale S Gregerson; Timothy J Tripp; John K McCormick; Patrick M Schlievert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-09-30
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  188     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-10     Completed Date:  2003-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1142-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins*
Cyclosporine / pharmacology*
Enterotoxins / radiation effects*,  toxicity*
Female
Immunosuppression
Immunosuppressive Agents / pharmacology*
Mice
Mice, Inbred BALB C
Rabbits
Shock, Septic / immunology,  microbiology,  mortality*
Staphylococcal Infections / immunology,  microbiology,  mortality
Staphylococcus aureus / metabolism,  pathogenicity
Superantigens / radiation effects,  toxicity
T-Lymphocytes
Whole-Body Irradiation*
Grant Support
ID/Acronym/Agency:
AI22159/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Enterotoxins; 0/Immunosuppressive Agents; 0/Superantigens; 0/enterotoxin F, Staphylococcal; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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