| Effects of topical petrolatum and salicylic acid upon skin photoreaction to UVA. | |
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MedLine Citation:
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PMID: 15908297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various agents which can be used in combination can also interfere with phototherapy. In this study, the effects of topical petrolatum and 20% salicylic acid in petrolatum upon skin photoreaction to UVA were investigated, in an in vivo test. Minimal phototoxic dose (MPD) test was performed on 31 volunteers and the test was repeated with thin (0.1 cc/25 cm(2)) petrolatum, thick (0.3 cc/25 cm(2)) petrolatum, thin 20% salicylic acid in petrolatum, thick 20% salicylic acid in petrolatum and sunscreen. The effect of each agent on MPD was investigated. MPD was increased with thin and thick applications of all agents. Also, MPD was increased with 20% salicylic acid in petrolatum when compared with pure petrolatum, in the same thickness. The application of petrolatum and salicylic acid in petrolatum just before PUVA therapy is not recommended because of their blocking effects. |
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Authors:
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Bahar Birgin; Emel Fetil; Turna Ilknur; Ali Tahsin Güneş; Sebnem Ozkan |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: 15 ISSN: 1167-1122 ISO Abbreviation: Eur J Dermatol Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-05-23 Completed Date: 2005-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: France |
Other Details:
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Languages: eng Pagination: 156-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Dokuz Eylül, Faculty of Medicine, 35340 Izmir, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Combined Modality Therapy Dermatitis, Phototoxic / prevention & control Dose-Response Relationship, Radiation Female Humans Male Petrolatum / administration & dosage*, chemistry Photosensitizing Agents / administration & dosage, chemistry Psoriasis / diagnosis*, therapy* Salicylic Acid / administration & dosage*, chemistry Sensitivity and Specificity Severity of Illness Index Single-Blind Method Skin / drug effects, radiation effects* Skin Tests Ultraviolet Therapy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 69-72-7/Salicylic Acid; 8009-03-8/Petrolatum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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