| Effects of topical petrolatum and salicylic acid on the erythemogenicity of UVB. | |
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MedLine Citation:
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PMID: 11872412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various topical agents used in combination with phototherapy have blocking effects, however in contrast to in vitro studies there were not enough in vivo studies about this subject. Our purpose was to examine the photoprotective effects of white petrolatum and salicylic acid which can be used before UVB therapy in psoriasis patients. In 35 volunteers, a phototest was performed to determine the minimal erythema dose (MED) and the test was repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) petrolatum, thin and thick salicylic acid (20%) in petrolatum and sunscreen. After 24 hrs, the effects of each agent on MED was investigated. MED values detected after pure UVB and after application of topical agents were compared one by one, and the differences between all of them have been found statistically significant. These showed that MED values were increased by thin or thick petrolatum and also by thin and thick salicylic acid (20%) in petrolatum. The highest MED values were detected with thick salicylic acid in petrolatum followed by thin salicylic acid in petrolatum, thick petrolatum and thin petrolatum. The application of petrolatum and salicylic acid, which can block UVB, before phototherapy is not recommended. |
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Authors:
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Emel Fetil; Sebnem Ozka; Mahmut Cüneyt Soyal; Turna Ilknur; Yasemin Erdem; Ali Tahsin Güneş |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of dermatology : EJD Volume: 12 ISSN: 1167-1122 ISO Abbreviation: Eur J Dermatol Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-03-01 Completed Date: 2002-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9206420 Medline TA: Eur J Dermatol Country: France |
Other Details:
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Languages: eng Pagination: 154-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Faculty of Medicine, University of Dokuz Eyl l, Inciralt 35340 Izmir, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Emollients
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administration & dosage,
chemistry* Erythema / etiology Humans Keratolytic Agents / administration & dosage, chemistry* Petrolatum / administration & dosage, chemistry* Psoriasis / radiotherapy* Salicylic Acid / administration & dosage, chemistry* Single-Blind Method Skin / drug effects Ultraviolet Therapy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Emollients; 0/Keratolytic Agents; 69-72-7/Salicylic Acid; 8009-03-8/Petrolatum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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