Document Detail

Effects of topical petrolatum and salicylic acid on the erythemogenicity of UVB.
MedLine Citation:
PMID:  11872412     Owner:  NLM     Status:  MEDLINE    
Various topical agents used in combination with phototherapy have blocking effects, however in contrast to in vitro studies there were not enough in vivo studies about this subject. Our purpose was to examine the photoprotective effects of white petrolatum and salicylic acid which can be used before UVB therapy in psoriasis patients. In 35 volunteers, a phototest was performed to determine the minimal erythema dose (MED) and the test was repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) petrolatum, thin and thick salicylic acid (20%) in petrolatum and sunscreen. After 24 hrs, the effects of each agent on MED was investigated. MED values detected after pure UVB and after application of topical agents were compared one by one, and the differences between all of them have been found statistically significant. These showed that MED values were increased by thin or thick petrolatum and also by thin and thick salicylic acid (20%) in petrolatum. The highest MED values were detected with thick salicylic acid in petrolatum followed by thin salicylic acid in petrolatum, thick petrolatum and thin petrolatum. The application of petrolatum and salicylic acid, which can block UVB, before phototherapy is not recommended.
Emel Fetil; Sebnem Ozka; Mahmut Cüneyt Soyal; Turna Ilknur; Yasemin Erdem; Ali Tahsin Güneş
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  12     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-01     Completed Date:  2002-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  154-6     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, University of Dokuz Eyl l, Inciralt 35340 Izmir, Turkey.
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MeSH Terms
Emollients / administration & dosage,  chemistry*
Erythema / etiology
Keratolytic Agents / administration & dosage,  chemistry*
Petrolatum / administration & dosage,  chemistry*
Psoriasis / radiotherapy*
Salicylic Acid / administration & dosage,  chemistry*
Single-Blind Method
Skin / drug effects
Ultraviolet Therapy / methods*
Reg. No./Substance:
0/Emollients; 0/Keratolytic Agents; 69-72-7/Salicylic Acid; 8009-03-8/Petrolatum

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