Document Detail

Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study.
MedLine Citation:
PMID:  16797821     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the dermal collagen of 15 postmenopausal women who had being treated with systemic estrogen replacement before and after using topical a 0.01% estrogen treatment. METHODS: Fifteen patients were included in this clinical trial using the systemic estrogen therapy for at least 1 year (minimum and maximum lengths of therapy were 13 and 40 months, respectively). A facial punch was performed in the preauricular area for collecting samples before and after the 16 weeks of treatment. Blood samples were also collected for estradiol level determination. The morphometric determination of epithelial and dermal thickness as well as dermal collagen were measured using a suitable software. The paired Student's t-test was used for statistical analysis. RESULTS: The epithelial and dermal thickness enhanced after the topic estrogen therapy (P<0.01). The amount of collagen significantly increased after 16 weeks of treatment (P<0.001). The estrogen levels did not significant increase after the topical therapy (P > or = 0.05). CONCLUSION: Our data suggested that topical estrogen associated to systemic estrogen therapy seems to increase the expression of skin collagen amount, which may prove to be beneficial for the postmenopausal facial skin.
Marisa T Patriarca; Katy Z Goldman; José M Dos Santos; Valéria Petri; Ricardo Santos Simões; José M Soares; Manuel J Simões; Edmund C Baracat
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-06-23
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  130     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  202-5     Citation Subset:  IM    
Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Administration, Cutaneous
Collagen / drug effects*,  metabolism
Drug Synergism
Estradiol / administration & dosage*,  blood
Estrogen Replacement Therapy*
Extracellular Matrix / drug effects*
Middle Aged
Postmenopause / drug effects
Skin / anatomy & histology,  drug effects*
Skin Aging / drug effects*
Reg. No./Substance:
50-28-2/Estradiol; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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