Document Detail

Effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats.
MedLine Citation:
PMID:  18764696     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the macroscopic effects of topical application of taurolidine on second intention healing of experimentally induced wounds in rats. ANIMALS: 32 adult Sprague-Dawley female rats. PROCEDURES: In each rat, 2 skin wounds were created in the lumbar area. Groups of 7 rats were assigned to have 1 wound treated topically with hydroxycellulose gel (HDCG), 2% taurolidine in HDCG (T-HDCG), 2% taurolidine-sodium citrate solution, or bacitracin-neomycin-polymyxin B ointment; the other wound was not treated. Four control rats (8 untreated wounds) were used. Wounds were monitored for contraction, epithelialization, and complete healing at 4, 8, and 14 days after wound creation. The number of days to complete healing was also recorded for each wound. RESULTS: Compared with other treatments or untreated wounds, wounds treated with T-HDCG had decreased total healing at day 8 and decreased epithelialization and decreased total healing at day 14. Wounds treated with T-HDCG required approximately 3 days longer to completely heal than all other treated and untreated wounds. Application of bacitracinneomycin-polymyxin B ointment did not enhance wound healing. Mean time to complete healing of untreated wounds in all treatment and control groups was 10.00 to 10.14 days. CONCLUSIONS AND CLINICAL RELEVANCE: In rats, topical application of T-HDCG to wounds had a negative effect on second intention healing by delaying the epithelialization process. In mammals, generally, wounds treated topically with taurolidine may need to be treated and monitored for a longer period than other wounds treated with other common woundhealing compounds or untreated wounds.
Jennifer M Simpson; Bernard Séguin; Alix I Gitelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  69     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1210-6     Citation Subset:  IM    
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
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MeSH Terms
Administration, Cutaneous
Analysis of Variance
Anti-Infective Agents / pharmacology*
Random Allocation
Rats, Sprague-Dawley
Taurine / analogs & derivatives*,  pharmacology
Thiadiazines / pharmacology*
Time Factors
Wound Healing / drug effects*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Thiadiazines; 107-35-7/Taurine; 19388-87-5/taurolidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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