| Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model. | |
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MedLine Citation:
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PMID: 21951062 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We investigated the effect of topical epigallocatechin-3-gallate (EGCG) on testosterone (T)-induced hair loss in mice. Marked hair loss was observed at the T-injected site, and topical EGCG significantly reduced the hair loss (P < 0.05). TUNEL staining showed apoptosis of follicular epithelial cells in the T-injected groups where topical EGCG was found to significantly diminish T-induced apoptosis (P < 0.05). Topical EGCG down-regulated the T-induced expression of androgen receptor but did not down-regulate 17β-hydroxysteroid dehydrogenase (HSD) and three β-HSD expression. Analysis using liquid chromatography tandem mass spectrometry (LC-MS/MS) on serum and tissue samples revealed no significant difference in T and dihydrotestosterone concentrations between the T-injected and T + EGCG groups. Thus, we found that T injection in a mouse model induces hair loss by apoptosis of the hair follicles rather than through the androgen metabolic pathway and also saw that T-induced apoptosis of hair follicles was reduced by topical EGCG. |
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Authors:
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Yoon Young Kim; Sun Up No; Min Ho Kim; Hei Sung Kim; Hoon Kang; Hyung Ok Kim; Young Min Park |
Publication Detail:
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Type: LETTER Date: 2011-7-27 |
Journal Detail:
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Title: Experimental dermatology Volume: - ISSN: 1600-0625 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Cha and Park Skin Clinic, Uijeonbu, Korea Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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