Document Detail


Effects of topical 10% ascorbate solution on established corneal ulcers after severe alkali burns.
MedLine Citation:
PMID:  7061209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When established corneal ulcers induced by alkali burning were treated with 10% ascorbate drops, no perforation occurred, in contrast to a 25% incidence in the control group. If perforations and descemetoceles were grouped together, these difference became insignificant (i.e., 14.2% ascorbate-treated vs. 25% control). Prolongation of descemetocele presence without perforation in the ascorbate-treated group indicated some therapeutic effect. We conclude that topical ascorbate does not substantially alter the outcome of established corneal ulcers.
Authors:
R R Pfister; C A Paterson; S A Hayes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  22     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Alkalies / adverse effects
Animals
Ascorbic Acid / therapeutic use*
Burns, Chemical / complications*
Corneal Ulcer / drug therapy*,  etiology
Eye Burns / complications*
Rabbits
Grant Support
ID/Acronym/Agency:
EY 02018/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Alkalies; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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