Document Detail


Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.
MedLine Citation:
PMID:  16179749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since tomato consumption is associated with decreased risk of prostate cancer, cell proliferation, cell cycle progression and apoptosis by LNCaP human prostate cancer cells might elucidate action of tomatoes. To discover possible bioactive fractions of tomatoes, whole tomato paste and its water and hexane extract were used and biomarkers of carcinogenesis were measured. After 6, 24 and 48 hr of incubation, cells were harvested and determined cell growth. Tomato paste hexane extract inhibited cell proliferation by 33% compared to the control after 48 hr incubation. Whole tomato paste and its water extract showed only modest growth inhibition. Tomato paste hexane extract at 5 microM lycopene increased G2/M-phase of the cell cycle from 13 to 28% and decreased S-phase cells from 45 to 29%. Apoptosis was observed at the 5 microM hexane extract at the late stages during 24 and 48 hr treatment. Tomato, therefore, deserves study as a potential chemopreventive/chemotherapeutic agent.
Authors:
Eun-Sun Hwang; Phyllis E Bowen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  23     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-23     Completed Date:  2005-11-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Affiliation:
Department of Human Nutrition, University of Illinois, Chicago, IL 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Annexin A5 / metabolism
Apoptosis / drug effects*
Carotenoids / analysis
Cell Cycle / drug effects*
Cell Proliferation / drug effects*
Flow Cytometry
Hexanes
Humans
Lycopersicon esculentum / chemistry*
Male
Phenols / analysis
Plant Extracts / pharmacology*
Prostatic Neoplasms / physiopathology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Annexin A5; 0/Hexanes; 0/Phenols; 0/Plant Extracts; 36-88-4/Carotenoids; 502-65-8/lycopene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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