| Effects of tolbutamide on blood flow in islets and exocrine tissue of the rat pancreas. | |
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MedLine Citation:
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PMID: 3899682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of tolbutamide (20 mg/kg and 100 mg/kg i.v.) on blood flow to the entire pancreatic gland and to its endocrine tissue was studied in anaesthetized rats. Non-radioactive microspheres 8.8 micron diameter were used for determination of local blood flow rates. The islet tissue was subsequently stained intravitally with dithizone. The organ was subdivided into small samples, frozen and thawed then scanned in the microscope for spheres in endocrine and exocrine tissue, respectively. Tolbutamide only insignificantly affected total organ blood flow (0.53 ml X min-1 X g-1, controls; 0.61 ml X min-1 X g-1 lower dose; 0.39 ml X min-1 X g-1 higher dose) but significantly increased the percent islet perfusion (3.0% controls; 6.6% lower dose; 10.5% higher dose of tolbutamide). The results favour the view that these vascular effects might facilitate insulin release into the systemic circulation. |
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Authors:
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F Vetterlein; D Senske; C Bornkessel; G Schmidt |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 113 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-11-08 Completed Date: 1985-11-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 395-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Blood Pressure / drug effects Diet Dithizone / pharmacology Islets of Langerhans / blood supply* Male Microspheres Pancreas / blood supply* Rats Rats, Inbred Strains Regional Blood Flow / drug effects Tolbutamide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 60-10-6/Dithizone; 64-77-7/Tolbutamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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