| Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD. | |
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MedLine Citation:
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PMID: 20580216 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: It is currently unclear whether the additive effects of a long-acting beta(2)-agonist (LABA) and the antimuscarinic tiotropium bromide (TIO) on resting lung function are translated into lower operating lung volumes and improved exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). METHODS: On a double-blind and cross-over study, 33 patients (FEV(1) = 47.4 +/- 12.9% predicted) were randomly allocated to 2-wk formoterol fumarate 12 microg twice-daily (FOR) plus TIO 18 microg once-daily or FOR plus placebo (PLA). Inspiratory capacity (IC) was obtained on constant-speed treadmill tests to the limit of tolerance (Tlim). RESULTS: FOR-TIO was superior to FOR-PLA in increasing post-treatment FEV(1) and Tlim (1.34 +/- 0.42 L vs. 1.25 +/- 0.39 L and 124 +/- 27% vs. 68 +/- 14%, respectively; p < 0.05). FOR-TIO slowed the rate of decrement in exercise IC compared to FOR-PLA (Deltaisotime-rest = -0.27 +/- 0.40 L vs. -0.45 +/- 0.36 L, p < 0.05). In addition, end-expiratory lung volume (% total lung capacity) was further reduced with FOR-TIO (p < 0.05). Of note, patients showing greater increases in Tlim with FOR-TIO (16/26, 61.6%) had more severe airways obstruction and lower exercise capacity at baseline. Improvement in Tlim with FOR-TIO was also related to larger increases in FEV(1) (p < 0.05). CONCLUSIONS: Compared to FOR monotherapy, FOR-TIO further improved effort-induced dynamic hyperinflation and exercise endurance in patients with moderate-to-severe COPD. These beneficial consequences were more likely to be found in severely-disabled patients with larger resting functional responses to the combination therapy. Trial registration: Clinicaltrials.gov Identifier: NCT00680056 [ClinicalTrials.gov]. |
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Authors:
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Danilo C Berton; Michel Reis; Ana Cristina B Siqueira; Adriano C Barroco; Luciana S Takara; Daniela M Bravo; Solange Andreoni; J Alberto Neder |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-06-26 |
Journal Detail:
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Title: Respiratory medicine Volume: 104 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1288-96 Citation Subset: IM |
Affiliation:
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Department of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil. dcberton@gmail.com |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00680056 |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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