Document Detail

Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: population-based study.
MedLine Citation:
PMID:  18450656     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Late-gestational serotonin reuptake inhibitor (SRI) exposure has been linked to adverse neonatal outcomes; however, the impact of timing and duration of exposure is unknown. AIMS: To determine whether late-gestational exposure to an SRI is associated with increased risk of adverse neonatal outcome relative to early exposure. METHOD: Population-based maternal and neonatal health records were linked to prenatal maternal prescription records for an SRI medication (n=3500). RESULTS: After controlling for maternal illness and duration of exposure, using propensity score matching, neonatal outcomes did not differ between late and early exposure (P>0.05). After controlling for maternal illness, longer prenatal exposure increased the risks of lower birth weight, respiratory distress and reduced gestational age (P<0.05). CONCLUSIONS: Using population health data, length of gestational SRI exposure, rather than timing, increased the risk for neonatal respiratory distress, lower birth weight and reduced gestational age, even when controlling for maternal illness and medication dose. These findings highlight the importance of distinguishing the specific impact of medication exposure from exposure to maternal illness itself.
Tim F Oberlander; William Warburton; Shaila Misri; Jaafar Aghajanian; Clyde Hertzman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  192     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-08-28     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Early Human Experience Unit, Centre for Community Child Health Research, Vancouver, BC, Canada.
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MeSH Terms
Birth Weight / drug effects*
Data Interpretation, Statistical
Depressive Disorder / drug therapy
Gestational Age
Health Care Surveys
Infant, Newborn
Infant, Newborn, Diseases / chemically induced*,  epidemiology
Pregnancy Complications / drug therapy*
Pregnancy Trimesters
Prenatal Exposure Delayed Effects / chemically induced*,  epidemiology
Serotonin Uptake Inhibitors / administration & dosage,  adverse effects*
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Serotonin Uptake Inhibitors
Comment In:
Evid Based Ment Health. 2009 Feb;12(1):27   [PMID:  19176786 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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