| Effects of tilisolol on ischemic myocardial metabolism in dogs. | |
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MedLine Citation:
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PMID: 7988643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of tilisolol on ischemic myocardial energy and carbohydrate metabolism were examined, and compared with those of propranolol. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min in anesthetized open-chest dogs, 5 min after saline, tilisolol (0.2 mg.kg-1, i.v.), or propranolol (1 mg.kg-1, i.v.) injection. During ischemia, the myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered, associated with ST segment elevation and TQ segment depression of the epicardial electrocardiogram. Tilisolol prevented the myocardial energy depletion and alterations of carbohydrate metabolism caused by 3 min of ischemia, to the same extent as did propranolol. Even 30 min after ischemia, the prevention of these ischemic changes was sustained by tilisolol, but not by propranolol. Tilisolol briefly reduced the ST segment elevation and TQ segment depression induced by ischemia. These results suggest that the protective effects of tilisolol on the ischemic myocardium are more potent and long-lasting than those of propranolol. |
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Authors:
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N Hayase; K Chiba; Y Abiko; K Ichihara |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 260 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-01-09 Completed Date: 1995-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 183-90 Citation Subset: IM |
Affiliation:
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Department of Hospital Pharmacy, Asahikawa Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
pharmacology*,
therapeutic use Animals Anti-Arrhythmia Agents / administration & dosage, pharmacology*, therapeutic use Carbohydrate Metabolism Coronary Vessels / metabolism Disease Models, Animal Dogs Electrocardiography / drug effects Energy Metabolism / drug effects Female Frozen Sections Heart / drug effects* Hemodynamics / drug effects Isoquinolines / administration & dosage, pharmacology*, therapeutic use Ligation Male Myocardial Ischemia / drug therapy*, metabolism, physiopathology Myocardium / enzymology, metabolism* Propranolol / administration & dosage, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Isoquinolines; 525-66-6/Propranolol; 85136-71-6/tilisolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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