Document Detail


Effects of tilisolol on ischemic myocardial metabolism in dogs.
MedLine Citation:
PMID:  7988643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of tilisolol on ischemic myocardial energy and carbohydrate metabolism were examined, and compared with those of propranolol. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min in anesthetized open-chest dogs, 5 min after saline, tilisolol (0.2 mg.kg-1, i.v.), or propranolol (1 mg.kg-1, i.v.) injection. During ischemia, the myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered, associated with ST segment elevation and TQ segment depression of the epicardial electrocardiogram. Tilisolol prevented the myocardial energy depletion and alterations of carbohydrate metabolism caused by 3 min of ischemia, to the same extent as did propranolol. Even 30 min after ischemia, the prevention of these ischemic changes was sustained by tilisolol, but not by propranolol. Tilisolol briefly reduced the ST segment elevation and TQ segment depression induced by ischemia. These results suggest that the protective effects of tilisolol on the ischemic myocardium are more potent and long-lasting than those of propranolol.
Authors:
N Hayase; K Chiba; Y Abiko; K Ichihara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  260     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-09     Completed Date:  1995-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Affiliation:
Department of Hospital Pharmacy, Asahikawa Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*,  therapeutic use
Animals
Anti-Arrhythmia Agents / administration & dosage,  pharmacology*,  therapeutic use
Carbohydrate Metabolism
Coronary Vessels / metabolism
Disease Models, Animal
Dogs
Electrocardiography / drug effects
Energy Metabolism / drug effects
Female
Frozen Sections
Heart / drug effects*
Hemodynamics / drug effects
Isoquinolines / administration & dosage,  pharmacology*,  therapeutic use
Ligation
Male
Myocardial Ischemia / drug therapy*,  metabolism,  physiopathology
Myocardium / enzymology,  metabolism*
Propranolol / administration & dosage,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Isoquinolines; 525-66-6/Propranolol; 85136-71-6/tilisolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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