Document Detail

Effects of ticlopidine on blood fibrinogen and blood viscosity in peripheral atherosclerotic disease.
MedLine Citation:
PMID:  4096744     Owner:  NLM     Status:  MEDLINE    
Ten patients with peripheral atherosclerotic disease(PAD) treated with 750 mg/d of 5-(2-chlorophenylmethyl)-4,5,6,7-tetrahydrothieno (3,5-c-pyridine) hydrochloride (ticlopidine, Tiklid) were studied for three months. As control was studied a similar group of patients treated with a traditional vasodilator (nicotinate). The aim of our study was to evaluate the effect of ticlopidine both on the clinical evolution of the disease and on rheologic, coagulative and platelet parameters. A progressive increase of maximal walking distance was noted during the three months of therapy with ticlopidine and limited to the first 30 days of treatment with nicotinate. The fibrinogen levels resulted significantly lowered during 90 days of treatment with ticlopidine, while that was not evident in the nicotinate group. There was also a slight improvement of blood viscosity in the ticlopidine group (not evident in the nicotinate group), but it was not statistically significant. No further modifications of investigated data were found in the two groups of patients. The clinical benefit of ticlopidine in PAD without adverse reactions can be confirmed at least at the dosage of 750 mg/d instead of the usual dose of 500 mg/d. A direct or indirect action of ticlopidine on plasma fibrinogen is suggested. This observation may supply new clues for the understanding of the mechanism of action of this drug.
M L Randi; F Fabris; M E Crociani; F Battocchio; A Girolami
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  35     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1985  
Date Detail:
Created Date:  1986-04-09     Completed Date:  1986-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1847-9     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis / blood*
Blood Coagulation / drug effects
Blood Platelets / drug effects
Blood Viscosity / drug effects*
Fibrinogen / metabolism*
Middle Aged
Nicotinic Acids / pharmacology
Thiophenes / adverse effects,  pharmacology*
Reg. No./Substance:
0/Nicotinic Acids; 0/Thiophenes; 55142-85-3/Ticlopidine; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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