| Effects of thyrotropin-releasing hormone on pancreatic exocrine secretion in the dog. | |
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MedLine Citation:
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PMID: 3925908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of thyrotropin-releasing hormone (TRH) on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas preparations. During constant intra-arterial infusion of secretin (0.03-0.05 units/min), concentrations of protein and bicarbonate in the pancreatic juice were measured before and after intra-arterial injection of TRH (0.1-10 ng). TRH did not produce any significant changes in the flow rate of pancreatic juice and in the rate of pancreatic blood flow. TRH caused a significant suppression of protein and bicarbonate output in a dose-dependent manner. At 10 ng of TRH, this suppression lasted about 20 min. From these data, it is suggested that TRH acts directly on both acinar and ductular cells of the pancreas and inhibits the secretions of digestive enzymes and bicarbonate. |
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Authors:
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F Yamagishi; F Iijima; K Iwatsuki; I Komiya; T Yamada; S Chiba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 274 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-08-22 Completed Date: 1985-08-22 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicarbonates / metabolism Dogs Female Male Pancreas / blood supply, secretion* Pancreatic Juice / metabolism Proteins / metabolism Regional Blood Flow / drug effects Secretin / pharmacology Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Proteins; 1393-25-5/Secretin; 24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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