| Effects of thyrotropin releasing hormone on hypothalamic thermosensitive neurons of the rat. | |
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MedLine Citation:
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PMID: 6791769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The actions of thyrotropin releasing hormone (TRH) were tested on the firing rat of temperature-sensitive and temperature-insensitive neurons in the rat preoptic/anterior area of the hypothalamus (POA). Iontophoretic application of TRH resulted in inhibition of the firing rate of temperature-insensitive, warm-sensitive and cold-sensitive neurons. The inhibitory response of cold sensitive neurons in TRH was relatively mild, however, and 2 of 6 of these neurons inhibited by TRH also displayed rebound increases in discharge rate following cessation of TRH application. These results parallel the hyperthermic effects of microinjected TRH and lend further support of the hypothesis that TRH acts as a neurotransmitter or neuromodulator in the POA portion of the CNS thermoregulatory network. |
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Authors:
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S K Salzman; A L Beckman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Brain research bulletin Volume: 7 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Evoked Potentials / drug effects Female Hypothalamus / drug effects* Male Neural Inhibition / drug effects Neurons / drug effects Preoptic Area / drug effects Rats Rats, Inbred Strains Thermoreceptors / drug effects* Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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