Document Detail


Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
MedLine Citation:
PMID:  11484889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental evidence suggests an involvement of thyroid hormones in myocardial nonmyocyte component growth. We evaluated the possible role of thyroid hormones in myocardial remodeling by ultrasonic tissue characterization (videodensitometry) in 8 hyperthyroid patients, in 10 hypothyroid patients, and in 2 patients with thyroid hormone resistance syndrome (RTH), before, 60, and 120 days after treatment (T0, T60, T120), and in 10 age-matched euthyroids. According to a previously described procedure, the derived collagen volume fraction (dCVF%, an echocardiographic index estimating the collagen content) was predicted from the pixel-level frequency distribution width (broadband, Bb) of the selected echocardiographic images. Thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were assessed by immunometric method. QT interval dispersion (QTd) on basal electrocardiogram was measured as a marker of dyshomogeneous ventricular repolarization. At T0, Bb and dCVF% were normal in hyperthyroid and euthyroid patients, and slightly increased in RTH patients, whereas significantly higher values were found in hypothyroids. At T60, a significant reduction in Bb was observed in hypothyroids, with nearly normal dCVF% values. This trend was confirmed at T120 with complete normalization of echoreflectivity. No echoreflectivity changes were observed in hyperthyroid and RTH patients during treatment. QTd was significantly increased in hypothyroids at T0, while no significant differences were found among groups at T60 and T120. Because the different videodeonsitometric myocardial properties observed in hypothyroid versus hyperthyroid patients correspond to an increase of dCVF%, this study suggests that thyroid hormones exert an inhibitory effect on myocardial collagen synthesis in humans.
Authors:
M M Ciulla; R Paliotti; D Cortelazzi; G Tortora; M V Barelli; V Buonamici; F Magrini; P Beck-Peccoz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  11     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2001-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-9     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine, Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore Policlinico IRCCS, Italy. img.lab@mailserver.unimi.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithyroid Agents / therapeutic use
Collagen / metabolism
Echocardiography*
Electrocardiography
Female
Humans
Hyperthyroidism / drug therapy,  physiopathology
Hypothyroidism / drug therapy,  physiopathology
Male
Methimazole / therapeutic use
Middle Aged
Thyroid Diseases / physiopathology,  therapy*,  ultrasonography*
Thyroid Hormone Resistance Syndrome / drug therapy,  physiopathology
Thyroid Hormones / physiology*
Thyroxine / therapeutic use
Triiodothyronine / analogs & derivatives*,  therapeutic use
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 0/Thyroid Hormones; 51-24-1/3,3',5-triiodothyroacetic acid; 60-56-0/Methimazole; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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