Document Detail


Effects of thyroid hormone on myocardial adrenergic beta-receptor responsiveness and function during late gestation.
MedLine Citation:
PMID:  1318539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of fetal hypothyroidism during late gestation on postnatal cardiovascular responsiveness, we measured heart rate and cardiac output responses to isoproterenol in newborn lambs. To evaluate the effect of such altered thyroid status on the development of beta-adrenergic signaling cascade, we measured myocardial beta-adrenergic receptor concentration and affinity, guanine nucleotide regulatory protein density, and adenylyl cyclase responsiveness. Twenty fetal lambs underwent either thyroidectomy and line placement or line placement alone at 128-130 d gestation. Five thyroidectomized and six control newborns were treated with isoproterenol, five thyroidectomized and four control newborns were killed upon delivery and tissue was obtained for biochemical studies, and four additional animals were delivered and killed at 126 d gestation and tissue was obtained for receptor analysis. Of the newborns treated with isoproterenol, the thyroidectomized lambs showed lower increase in heart rate and cardiac output compared with euthyroid newborns. Compared with the myocardium of normal newborns of similar gestation, the myocardium of the newborns who underwent fetal thyroidectomy failed to show the normal increase in beta-adrenoceptors accompanied by reduction in beta-adrenergic-stimulated adenylate cyclase activity. These results suggest that near term, the normal development of ovine fetus myocardial beta-adrenergic receptor is affected by thyroid hormones.
Authors:
E Birk; M R Tyndall; L C Erickson; A M Rudolph; J M Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  31     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-10     Completed Date:  1992-07-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-73     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / metabolism
Animals
Animals, Newborn
Cardiac Output / drug effects,  physiology
Female
Fetus / physiology
GTP-Binding Proteins / metabolism
Gestational Age
Heart Rate / drug effects,  physiology
Isoproterenol / pharmacology
Myocardium / metabolism*
Pregnancy
Receptors, Adrenergic, beta / drug effects,  physiology*
Sheep
Thyroid Hormones / physiology*
Thyroidectomy
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Thyroid Hormones; 7683-59-2/Isoproterenol; EC 3.6.1.-/GTP-Binding Proteins; EC 4.6.1.1/Adenylate Cyclase

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