| Effects of thyroid hormone on the adaptation in short bowel syndrome. | |
| | |
MedLine Citation:
|
PMID: 19111325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Thyroid hormone acts on structural and functional maturation of the mammalian small intestine, mitochondrial pathways, and several protein-gene interactions. Therefore, it is one of the most important regulators of intestinal epithelial differentiation. The aim of the study was to evaluate the effects of thyroid hormone on the adaptation in an experimental model of short bowel syndrome. METHODS: Rats were divided into three groups: sham (bowel transection and anastomosis), short bowel syndrome-saline (75% bowel resection and anastomosis), and short bowel syndrome-thyroid hormone (75% bowel resection and anastomosis, and was administered triiodothyronine). The evaluation of adaptation parameters, histopathological and biochemical analysis were performed in all groups. RESULTS: Triiodothyronine treatment resulted in a significant increase in adaptation parameters, villus height-crypt depth, and enterocyte proliferation, whereas significant decrease was seen in apoptotic index in jejunum. Enterocyte proliferation and most of the adaptation parameters changed significantly in ileum following the treatment with triiodothyronine as in jejunum. The changes in ileal villus height-crypt depth and apoptotic index were not statistically significant. Serum levels of free triiodothyronine were lower in the short bowel syndrome-saline group. CONCLUSIONS: Our results suggest that thyroid hormone treatment in the hypothyroid phase of SBS enhances intestinal adaptive response. |
| | |
Authors:
|
Osman Yuksel; Ertan Tatlicioglu; Aylar Poyraz; Tolga Sahin; Hatice Pasaoglu; Ozgur Ekinci; Bulent Salman; Utku Yilmaz |
Related Documents
:
|
7073135 - Definitive surgical therapy for incapacitating "gas-bloat" syndrome. 16521475 - Histopathological and immunohistochemical study of the enteric innervations among vario... 15951965 - An unusual case of turcot's syndrome associated with ileal adenocarcinoma, intestinal n... 105095 - Can therapeutic considerations provide clues to the etiology of aphthous stomatitis and... 19264735 - Smith-magenis syndrome with west syndrome in a 5-year-old girl: a long-term follow-up s... 1956715 - Congenital hypoplastic anemia, diabetes, and severe renal tubular dysfunction associate... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-30 |
Journal Detail:
|
Title: The Journal of surgical research Volume: 155 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-22 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 116-24 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Gazi University Medical School, Ankara, Turkey. osmanyuksel1971@yahoo.com.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects* Anastomosis, Surgical Animals Apoptosis / drug effects* Cell Proliferation / drug effects Enterocytes / drug effects* Ileum / pathology, surgery Jejunum / pathology, surgery Male Rats Rats, Wistar Short Bowel Syndrome / drug therapy*, pathology Triiodothyronine / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Implication of protein kinase a for a hepato-protective mechanism of milrinone pretreatment.
Next Document: The utilization of a biopsy needle to obtain small muscle tissue specimens to analyze the gene and p...