| Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes. | |
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MedLine Citation:
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PMID: 10662715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyroid hormones play an important role in cardiac electrophysiology through both genomic and nongenomic mechanisms of action. The effects of triiodothyronine (T(3)) on the electrophysiological properties of ventricular myocytes isolated from euthyroid and hypothyroid rats were studied using whole cell patch clamp techniques. Hypothyroid ventricular myocytes showed significantly prolonged action potential duration (APD(90)) compared with euthyroid myocytes, APD(90) of 151 +/- 5 vs. 51 +/- 8 ms, respectively. Treatment of hypothyroid ventricular myocytes with T(3) (0.1 microM) for 5 min significantly shortened APD by 24% to 115 +/- 10 ms. T(3) similarly shortened APD in euthyroid ventricular myocytes, but only in the presence of 4-aminopyridine (4-AP), an inhibitor of the transient outward current (I(to)), which prolonged the APD by threefold. Transient outward current (I(to)) was not affected by the acute application of T(3) to either euthyroid or hypothyroid myocytes; however, I(to) density was significantly reduced in hypothyroid compared with euthyroid ventricular myocytes. |
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Authors:
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Z Q Sun; K Ojamaa; W A Coetzee; M Artman; I Klein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 278 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-02 Completed Date: 2000-03-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E302-7 Citation Subset: IM |
Affiliation:
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Pediatric Cardiology, New York University Medical Center, New York 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminopyridine
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pharmacology Action Potentials / drug effects Animals Cadmium Chloride / pharmacology Electric Conductivity Heart / drug effects*, physiopathology* Heart Ventricles / drug effects, physiopathology Hypothyroidism / chemically induced, physiopathology Male Patch-Clamp Techniques Propylthiouracil Rats Rats, Sprague-Dawley Triiodothyronine / pharmacology* Triiodothyronine, Reverse / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-03775/HL/NHLBI NIH HHS; R01 HL-58849/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10108-64-2/Cadmium Chloride; 504-24-5/4-Aminopyridine; 51-52-5/Propylthiouracil; 5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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