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Effects of a three-month combined exercise program on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women.
MedLine Citation:
PMID:  21521346     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:  We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a three-month combined aerobic and resistance exercise program on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods:  Forty non-diabetic, obese women (body mass index = 27.6 ± 2.4 kg/m(2) ) were included in the study and were compared before and after a three-month exercise program, which was composed of 45 minutes of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 minutes of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results:  At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), HDL-cholesterol, fasting glucose, and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21, and fetuin-A levels (R(2) = 0.744). After the exercise program, BMI, waist circumference, SBP, diastolic blood pressure, and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0.001) along with modest decrease in FGF21 levels (P = 0.043). However, fetuin-A levels were not changed significantly (P = 0.202). Conclusions:  A three-month combined exercise program decrease the FGF21 levels as well as arterial stiffness in obese Korean women.
Authors:
Sae Jeong Yang; Ho Cheol Hong; Hae Yoon Choi; Hye Jin Yoo; Geum Ju Cho; Teak Geun Hwang; Sei Hyun Baik; Dong Seop Choi; Seon Mi Kim; Kyung Mook Choi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
Division of Endocrinology and Metabolism, Korea University College of Medicine, Seoul, Korea Guro-Gu Public Health Center, Seoul, Korea Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.
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