| Effects of a three-month combined exercise program on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. | |
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MedLine Citation:
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PMID: 21521346 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a three-month combined aerobic and resistance exercise program on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods: Forty non-diabetic, obese women (body mass index = 27.6 ± 2.4 kg/m(2) ) were included in the study and were compared before and after a three-month exercise program, which was composed of 45 minutes of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 minutes of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results: At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), HDL-cholesterol, fasting glucose, and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21, and fetuin-A levels (R(2) = 0.744). After the exercise program, BMI, waist circumference, SBP, diastolic blood pressure, and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0.001) along with modest decrease in FGF21 levels (P = 0.043). However, fetuin-A levels were not changed significantly (P = 0.202). Conclusions: A three-month combined exercise program decrease the FGF21 levels as well as arterial stiffness in obese Korean women. |
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Authors:
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Sae Jeong Yang; Ho Cheol Hong; Hae Yoon Choi; Hye Jin Yoo; Geum Ju Cho; Teak Geun Hwang; Sei Hyun Baik; Dong Seop Choi; Seon Mi Kim; Kyung Mook Choi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Endocrinology and Metabolism, Korea University College of Medicine, Seoul, Korea Guro-Gu Public Health Center, Seoul, Korea Department of Family Medicine, Korea University College of Medicine, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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