| Effects of three diterpenoids on tumour cell proliferation and telomerase activity. | |
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MedLine Citation:
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PMID: 19521915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10(-4)-10(-8) mol L(-1), three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs. |
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Authors:
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Yunshan Yang; Handong Sun; Yiping Zhou; Shuyu Ji; Malin Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product research Volume: 23 ISSN: 1478-6427 ISO Abbreviation: Nat. Prod. Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-12 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 1007-12 Citation Subset: IM |
Affiliation:
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Yunnan Pharmacological Laboratory for Natural Products, Kunming Medical College, Kunming, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation
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drug effects* Diterpenes / chemistry, pharmacology* Humans Isodon / chemistry K562 Cells Molecular Structure Telomerase / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/eriocalyxin B; 0/xerophilusin B; 93781-75-0/macrocalin B; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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