Document Detail


Effects of three diterpenoids on tumour cell proliferation and telomerase activity.
MedLine Citation:
PMID:  19521915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10(-4)-10(-8) mol L(-1), three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs.
Authors:
Yunshan Yang; Handong Sun; Yiping Zhou; Shuyu Ji; Malin Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product research     Volume:  23     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1007-12     Citation Subset:  IM    
Affiliation:
Yunnan Pharmacological Laboratory for Natural Products, Kunming Medical College, Kunming, PR China.
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MeSH Terms
Descriptor/Qualifier:
Cell Proliferation / drug effects*
Diterpenes / chemistry,  pharmacology*
Humans
Isodon / chemistry
K562 Cells
Molecular Structure
Telomerase / drug effects*
Chemical
Reg. No./Substance:
0/Diterpenes; 0/eriocalyxin B; 0/xerophilusin B; 93781-75-0/macrocalin B; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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