Document Detail

Effects of three diterpenoids on tumour cell proliferation and telomerase activity.
MedLine Citation:
PMID:  19521915     Owner:  NLM     Status:  MEDLINE    
Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10(-4)-10(-8) mol L(-1), three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs.
Yunshan Yang; Handong Sun; Yiping Zhou; Shuyu Ji; Malin Li
Related Documents :
15966765 - Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines.
20028875 - Dna damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant ...
9065745 - Effect of penclomedine (nsc-338720) on telomere fusions, chromatin blebbing, and cell v...
10793065 - Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.
861165 - The significance of free blood in liquid and solid tumours.
8043665 - Cancer antigen 125 is locally produced in the peritoneal cavity during continuous ambul...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product research     Volume:  23     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1007-12     Citation Subset:  IM    
Yunnan Pharmacological Laboratory for Natural Products, Kunming Medical College, Kunming, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Proliferation / drug effects*
Diterpenes / chemistry,  pharmacology*
Isodon / chemistry
K562 Cells
Molecular Structure
Telomerase / drug effects*
Reg. No./Substance:
0/Diterpenes; 0/eriocalyxin B; 0/xerophilusin B; 93781-75-0/macrocalin B; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dichloromethane extract of Dicerocaryum senecioides leaves exhibits remarkable anti-inflammatory act...
Next Document:  Fructose-derived carbohydrates from Alisma orientalis.