Document Detail

Effects of three different infant dentifrices on biofilms and oral microorganisms.
MedLine Citation:
PMID:  11314149     Owner:  NLM     Status:  MEDLINE    
The purpose of this work was to evaluate the effects of infant dentifrices: A--with lactoperoxidase, glucose oxidase and lactoferrin; B--with 1100 ppm of NaF and sodium lauryl sulfate; C--with extract of calendula. The dentifrices were test on biofilms formed in vitro from saliva and dental plaque of infants, using reference strains A. viscosus (ATCC 43146); C. albicans (ATCC 51501); L. casei (ATCC 4646); S. mitis (ATCC 49456); S. mutans (ATCC 25175); S. oralis (ATCC 35037); S. sanguis (ATCC 10586); S. sobrinus (ATCC 27609) and isolated clinically microorganisms C. albicans, S. mitis, S. mutans, S. oralis, S. sanguis, S. sobrinus and Lactobacillus sp. Twenty infants were chosen, who were beginning treatment at the Infants Clinic of the Pediatric Dentistry Department, Federal University of Rio de Janeiro. A pool of unstimulated saliva and a pool of dental plaque were collected from which biofilms were produced. Supernatants from each dentifrice were prepared and concentrated and diluted solutions of the dentifrices and a control sterile diluent were tested against the biofilms produced, for 1 and 3 minutes, and against the microorganisms. The results were statistically analyzed by the ANOVA and Tukey Test. After the exposure of the biofilms produced both from saliva and from dental plaque, to the dentifrice B concentrated and 1/2, for 1 and 3 minutes, the viable microorganisms count (CFU/ml), compared to the controls, was significantly reduced (p < 0.05). However, exposure to the dentifrices A and C concentrated and dentifrice B 1/4 and 1/8, for 1 and 3 minutes, was not significantly lethal to the biofilms. The dentifrices A and C, either concentrated or diluted (1/2 to 1/128) and the dentifrice B in the dilutions 1/16 to 1/128 did not have an antimicrobial effect on any microorganism evaluated. For all the microorganisms evaluated, the dentifrice B concentrated and in the 1/2 dilution showed a significant antimicrobial effect, when compared with the control (p < 0.05).
A Modesto; K C Lima; M de Uzeda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of clinical pediatric dentistry     Volume:  24     ISSN:  1053-4628     ISO Abbreviation:  J Clin Pediatr Dent     Publication Date:  2000  
Date Detail:
Created Date:  2001-04-20     Completed Date:  2001-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100079     Medline TA:  J Clin Pediatr Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  D    
School of Dentistry, Federal University of Rio de Janeiro, Brazil.
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MeSH Terms
Actinomyces viscosus / drug effects
Analysis of Variance
Anti-Infective Agents, Local / pharmacology*
Bacteria / drug effects*
Biofilms / drug effects*
Calendula / therapeutic use
Candida albicans / drug effects
Colony Count, Microbial
Dental Plaque / microbiology
Dentifrices / pharmacology*
Glucose Oxidase / pharmacology
Lactobacillus / drug effects
Lactobacillus casei / drug effects
Lactoferrin / pharmacology
Lactoperoxidase / pharmacology
Mouth / microbiology*
Plants, Medicinal
Saliva / microbiology
Sodium Dodecyl Sulfate / pharmacology
Sodium Fluoride / pharmacology
Statistics as Topic
Streptococcus / drug effects
Streptococcus mutans / drug effects
Streptococcus oralis / drug effects
Streptococcus sanguis / drug effects
Streptococcus sobrinus / drug effects
Surface-Active Agents / pharmacology
Time Factors
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Dentifrices; 0/Lactoferrin; 0/Surface-Active Agents; 151-21-3/Sodium Dodecyl Sulfate; 7681-49-4/Sodium Fluoride; EC Oxidase; EC 1.11.1.-/Lactoperoxidase

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