| Effects of thiopental on regulatory mechanisms of brain energy metabolism. | |
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MedLine Citation:
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PMID: 7329451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After administration of thiopental to artificially ventilated rats, the EEG, cerebral metabolism, intracellular distribution of hexokinase activity and the thiopental concentration in brain was measured. Considering the EEG changes, the time course of thiopental action was divided into an initial stage with increased beta activity and a following second stage with reduced beta activity. The glucose-6-phosphate concentration significantly increased in the first stage and fell again to the control level with the beginning of the second stage. Furthermore, during the second stage the glucose level increased and the hexokinase activity shifted from the mitochondrially bound form to the soluble form. From these results the following conclusions were drawn: Phosphofructokinase activity appeared inhibited only during the initial stage. During the second stage comparable to the stage of surgical anesthesia, thiopental solubilizes bound hexokinase activity inhibiting thereby energy metabolism. |
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Authors:
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J Krieglstein; G Sperling; G Twietmeyer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 318 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 56-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Blood Gas Analysis Blood Pressure / drug effects Brain / drug effects, metabolism* Electroencephalography Energy Metabolism / drug effects* Hexokinase / metabolism Male Rats Rats, Inbred Strains Thiopental / metabolism, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 76-75-5/Thiopental; EC 2.7.1.1/Hexokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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