Document Detail

Effects of thiopental on bispectral index and heart rate variability.
MedLine Citation:
PMID:  16507201     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Thiopental has been reported to reduce sympathetic tone, however, it is not clear whether change in heart rate variability is associated with depth of anaesthesia. The purpose of the present study was to evaluate changes in heart rate variability at different depths of hypnosis during induction of anaesthesia with thiopental. METHODS: We studied 17 ASA I patients scheduled for minor surgery. The depth of hypnosis was monitored by the BIS. Spectral analysis of heart rate variability using a maximum entropy method resulted in a characteristic power spectrum with two main regions, a high frequency and a low frequency. Haemodynamics, entropy, low frequency, high frequency and low frequency/high frequency were monitored in an awake state and after the induction of anaesthesia. RESULTS: Heart rate increased in a BIS-dependent manner, whereas blood pressure showed no significant changes during the study period. High frequency, entropy and low frequency decreased with a reduction in the BIS value. Low frequency/high frequency showed no significant change during the study period. CONCLUSIONS: Induction of anaesthesia with thiopental increased heart rate and decreased high frequency, entropy and low frequency in a BIS-dependent manner, indicating that thiopental reduces cardiac parasympathetic tone depending on the depth of hypnosis.
S Tsuchiya; N Kanaya; N Hirata; S Kurosawa; N Kamada; M Edanaga; M Nakayama; K Omote; A Namiki
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-03-01
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  23     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  454-9     Citation Subset:  IM    
Department of Anesthesiology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
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MeSH Terms
Analysis of Variance
Anesthetics, Intravenous / pharmacology*
Blood Pressure / drug effects
Electroencephalography / drug effects*
Heart Rate / drug effects*
Middle Aged
Oral Surgical Procedures
Surgical Procedures, Elective
Thiopental / pharmacology*
Reg. No./Substance:
0/Anesthetics, Intravenous; 76-75-5/Thiopental

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