Document Detail

Effects of thio-tepa and hydroxyurea on sperm production in Lakeview hamsters.
MedLine Citation:
PMID:  6799658     Owner:  NLM     Status:  MEDLINE    
The spermatogenic cell sensitivity in the induction of sperm abnormalities by two antineoplastic agents, thio-TEPA and hydroxyurea in inbred Lakeview hamsters was studied and the results were compared with those of similar investigations with mice. Testis weights, epididymal sperm numbers, and body weights were also monitored up to 12 wk after treatment. Thio-TEPA administration increased sperm abnormalities and reduced testis weights as well as sperm numbers in a dose-dependent manner at wk 4 and 12 after treatment. Hydroxyurea administration was ineffective in inducing sperm abnormalities, but testis weights and sperm numbers were adversely affected dose-dependent changes in body weights after treatment with either agent were also recorded. The findings with thio-TEPA on sperm morphology agree with those reported for the mouse. However, unlike the results of the mouse studies, hydroxy-urea effects on sperm shape were not observed in the hamster.
H Singh; C Taylor
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  8     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-16     Citation Subset:  IM    
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MeSH Terms
Hydroxyurea / pharmacology*
Sperm Count
Spermatozoa / drug effects*
Testis / drug effects
Thiotepa / pharmacology*
Grant Support
5506 RR 08144-06/RR/NCRR NIH HHS
Reg. No./Substance:
127-07-1/Hydroxyurea; 52-24-4/Thiotepa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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