Document Detail

Effects of theophylline, atenolol and their combination on myocardial ischemia in stable angina pectoris.
MedLine Citation:
PMID:  2239717     Owner:  NLM     Status:  MEDLINE    
The effects of theophylline (400 mg twice a day), atenolol (50 mg twice a day) and their combination on myocardial ischemia were studied in 9 patients with stable angina pectoris in a randomized, single-blind, triple crossover trial. Placebo was administered to the patients during the run-in and the run-off periods. A treadmill exercise test and 24-hour ambulatory electrocardiographic monitoring were obtained at the end of each treatment period. Compared with placebo, theophylline significantly improved the time to onset of myocardial ischemia (1 mm of ST-segment depression) from 7.8 +/- 3.7 to 9.5 +/- 3.7 minutes (p less than 0.03) and the exercise duration from 9 +/- 3.4 to 10.1 +/- 3.5 minutes (p less than 0.04). During atenolol and during combination treatment, the time to the onset of ischemia and the exercise duration were similar (10.8 +/- 4.2 and 11.2 +/- 3.2 minutes, 11.2 +/- 3.6 and 11.5 +/- 3.2 minutes, respectively) and longer than during theophylline administration (p less than 0.05). Ambulatory electrocardiographic monitoring showed that, during theophylline administration, the heart rate was higher than during placebo throughout the 24 hours (p less than 0.05). During atenolol and during combination treatment the heart rate was similar and in both cases lower than during placebo (p less than 0.05). Compared with placebo, theophylline decreased the total ischemic time from 97 +/- 110 to 70 +/- 103 minutes (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
F Crea; G Pupita; A R Galassi; H el-Tamimi; J C Kaski; G J Davies; A Maseri
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  66     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-14     Completed Date:  1990-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1157-62     Citation Subset:  AIM; IM    
Cardiovascular Unit, RPMS-Hammersmith Hospital, London, United Kingdom.
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MeSH Terms
Angina Pectoris / drug therapy*
Atenolol / administration & dosage,  therapeutic use*
Coronary Circulation / drug effects
Coronary Disease / drug therapy
Drug Therapy, Combination
Electrocardiography, Ambulatory
Exercise Test
Middle Aged
Single-Blind Method
Theophylline / administration & dosage,  therapeutic use*
Reg. No./Substance:
29122-68-7/Atenolol; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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