| Effects of testosterone on the development of endometrial tumors in female rats. | |
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MedLine Citation:
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PMID: 8349175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term treatment of mature virgin female rats with a high dose of testosterone (24 weeks at a total dose of 300 mg) was associated with the development of endometrial adenomatous hyperplasia and resulted in a high incidence of adenocarcinoma when administered in combination with 7,12-dimethyl-benz[a]anthracene (DMBA; 2 mg in 0.1 ml sesame oil) introduced into the uterine cavity. Adenomatous hyperplasia occurred in all testosterone-treated rats, both with and without ovaries. Testosterone may promote the induction of endometrial tumors by DMBA. |
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Authors:
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S Terada; N Suzuki; K Uchide; K Akasofu; E Nishida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 36 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-09-16 Completed Date: 1993-09-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene* Adenocarcinoma / chemically induced*, pathology Animals Endometrial Hyperplasia / chemically induced*, pathology Endometrial Neoplasms / chemically induced*, pathology Endometrium / pathology Female Rats Rats, Wistar Testosterone / administration & dosage, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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57-97-6/9,10-Dimethyl-1,2-benzanthracene; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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