Document Detail

Effects of terguride in patients with Huntington's disease.
MedLine Citation:
PMID:  2575450     Owner:  NLM     Status:  MEDLINE    
trans-Dihydrolisuride, a partial dopamine receptor agonist, was tested for its effects on chorea in a double-blind, crossover clinical study in 10 patients with Huntington's disease. In eight patients, a neurophysiological evaluation was also performed. No reduction in choreic movements or improvement in voluntary movement performance was observed. However, in some patients, there was a slight improvement in patients' alertness and a reduction of the movement reaction time.
F Stocchi; A Carta; A Berardelli; A Antonini; M Argenta; A Formica; A Agnoli
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  12     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  IM    
Department of Neuroscience, La Sapienza University, Rome, Italy.
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MeSH Terms
Affect / drug effects
Awareness / drug effects
Clinical Trials as Topic
Dopamine Agents / therapeutic use*
Double-Blind Method
Ergolines / therapeutic use*
Huntington Disease / drug therapy*
Lisuride / analogs & derivatives,  therapeutic use*
Middle Aged
Reg. No./Substance:
0/Dopamine Agents; 0/Ergolines; 18016-80-3/Lisuride; 37686-84-3/dironyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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