Document Detail

Effects of terbutaline on the pressure volume relationship in fetal rabbit lung.
MedLine Citation:
PMID:  211788     Owner:  NLM     Status:  MEDLINE    
The pressure-volume relationship in preterm rabbit lung was studied at 28 days of gestation. Injection of 0.1 mg terbutaline, a selective beta2-receptor stimulating drug, significantly increased the volume of air at equivalent low transpulmonary pressures, compared to a saline treated group and an untreated group. These findings indicate an increased pulmonary distensibility of the fetal rabbit lung after terbutaline administration. The mechanism of action is discussed and surfactant mediated effects are suggested to be the probable explanation.
B Bergman; T Hedner; P Lundborg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  57     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1978  
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
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MeSH Terms
Lung / drug effects,  embryology*
Lung Volume Measurements
Pulmonary Surfactants
Receptors, Adrenergic, beta / drug effects
Sodium Chloride / pharmacology
Terbutaline / pharmacology*
Reg. No./Substance:
0/Pulmonary Surfactants; 0/Receptors, Adrenergic, beta; 23031-25-6/Terbutaline; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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