Document Detail

Effects of tebufenozide on some aspects of lake trout (Salvelinus namaycush) immune response.
MedLine Citation:
PMID:  17537512     Owner:  NLM     Status:  MEDLINE    
Tebufenozide is a nonsteroid ecdysone agonist that causes premature and incomplete molting in Lepidoptera and is used on crops and in forest spray programs. Lake trout (Salvelinus namaycush) were exposed to one pulse of 0.25 ppm tebufenozide every 3 days (12 pulses in total). Cell ratios and respiratory burst responses of circulating white blood cells (WBCs) as well as head-kidney (HK) WBCs were investigated by using cell observation, Nitro-Blue Tetrazolium tests, and flow cytometry. Endpoints studied suggest a difference in sensitivity between HK and circulating blood cells to tebufenozide and show a stimulation of fish cell function and changes in percentages of cell types. Responses are not associated with a strong stress response as highlighted by the absence of effect on cortisol and blood protein levels. These results and tebufenozide persistence in water warrant further studies on pesticide impact on fish immunity when used on crops or in forest spray programs near lakes and streams.
D Hamoutene; J F Payne; H Volkoff
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-29
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  69     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
Science Branch, Department of Fisheries and Oceans-NWAFC, PO Box 5667, St John's, NL, Canada A1C 5X1.
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MeSH Terms
Fish Proteins / blood
Hydrazines / toxicity*
Hydrocortisone / blood
Insecticides / toxicity*
Leukocyte Count
Leukocytes / cytology,  drug effects*,  metabolism
Respiratory Burst / drug effects
Salmonidae / blood,  physiology*
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Fish Proteins; 0/Hydrazines; 0/Insecticides; 0/Water Pollutants, Chemical; 112410-23-8/tebufenozide; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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