Document Detail

Effects of taurine on depletion of erythrocyte membrane Na-K ATPase activity due to ozone exposure or cholesterol enrichment.
MedLine Citation:
PMID:  8926535     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to investigate the interrelationship between taurine and erythrocyte-membrane Na-K ATPase activity. A comparison was conducted to test whether taurine or uric acid (a water-soluble scavenger of free radicals) prevents or recovers the depletion in membrane ouabain-sensitive Na-K ATPase activity resulting from ozone exposure or cholesterol enrichment of the erythrocyte membrane. A depletion of 44% and 27% in ouabain-sensitive Na-K ATPase activity was respectively caused by ozone exposure and cholesterol enrichment. Taurine as well as uric acid partially prevented the activity loss from ozone exposure. In addition, taurine at high concentrations (from 1.5 to 4.5 mM) restored the depletion of erythrocyte-membrane Na-K ATPase activity due to ozone exposure and prevented the depletion of the enzyme activity due to cholesterol enrichment. In contrast, although the same high concentrations were used, uric acid failed to show either of the above effects. These results suggest that taurine acts (1.5-4.5 mM) polyvalently as not only an antioxidizing agent but also as a membrane stabilizer to maintain the functions of membrane Na-K ATPase, a membrane-bound protein.
B Qi; T Yamagami; Y Naruse; S Sokejima; S Kagamimori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  41     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-11-04     Completed Date:  1996-11-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Department of Community Health and Preventive Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Antioxidants / pharmacology*
Cholesterol / pharmacology*
Erythrocyte Membrane / drug effects,  enzymology*
Ozone / pharmacology*
Sodium-Potassium-Exchanging ATPase / blood*
Taurine / pharmacology*
Uric Acid / pharmacology
Reg. No./Substance:
0/Antioxidants; 10028-15-6/Ozone; 107-35-7/Taurine; 57-88-5/Cholesterol; 69-93-2/Uric Acid; EC ATPase

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