| Effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder application. | |
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MedLine Citation:
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PMID: 9627732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder (MH) application were evaluated in 18 ASA I and II patients undergoing scheduled intracranial surgery. Premedication consisted of hydroxyzine, alprazolam and atropine given orally 1 h before surgery. Anesthesia was provided with propofol and sufentanil using a target-controlled infusion device; constant calculated plasma concentrations of 4 micrograms ml-1 propofol and 0.5 ng ml-1 sufentanil were maintained throughout the study. Muscle relaxation was obtained with atracurium and ventilation was controlled with air/oxygen. The MH was fixed 45 +/- 12 min (mean +/- SD) after induction of anesthesia. Heart rate and systolic, diastolic, and mean non invasive arterial pressure were monitored and recorded 5 min before induction of anesthesia (control), 1 min before MH application (MH-1), at MH application, and 1 and 2 min after MH application. Systolic, diastolic, mean arterial pressure, and heart rate increased significantly during and after MH application when compared with MH-1 values, but remained constantly lower than control. Hemodynamic parameters measured 1 min before MH application were significantly lower than control. The results of the study indicate that target-controlled anesthesia maintained with constant calculated plasma concentrations of 4 micrograms ml-1 propofol and 0.5 ng ml-1 sufentanil prevents the increase in arterial pressure and heart rate beyond control values following MH application but may induce some degree of arterial hypotension in the absence of nociceptive stimulation. |
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Authors:
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P Hans; E Coussaert; F Cantraine; P Y Dewandre; J F Brichant; M Grevesse; M Lamy |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Belgica Volume: 49 ISSN: 0001-5164 ISO Abbreviation: Acta Anaesthesiol Belg Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-30 Completed Date: 1998-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421022 Medline TA: Acta Anaesthesiol Belg Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 7-11 Citation Subset: IM |
Affiliation:
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Department of Anesthesia & Intensive Care Medicine, University Hospital of Liège, Domaine Universitaire du Sart Tilman, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Anesthesia
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administration & dosage Alprazolam / therapeutic use Analysis of Variance Anesthesia, Intravenous / instrumentation, methods* Anesthetics, Intravenous / administration & dosage*, blood Atracurium / administration & dosage Atropine / administration & dosage Blood Pressure / drug effects*, physiology Brain / surgery Heart Rate / drug effects*, physiology Humans Hydroxyzine / therapeutic use Hypnotics and Sedatives / therapeutic use Hypotension / chemically induced Infusion Pumps Middle Aged Neuromuscular Blockade Neuromuscular Nondepolarizing Agents / administration & dosage Neurosurgery / instrumentation* Pain / physiopathology Preanesthetic Medication Propofol / administration & dosage*, blood Sufentanil / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Anesthesia; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 0/Neuromuscular Nondepolarizing Agents; 2078-54-8/Propofol; 28981-97-7/Alprazolam; 51-55-8/Atropine; 56030-54-7/Sufentanil; 64228-79-1/Atracurium; 68-88-2/Hydroxyzine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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