Document Detail

Effects of target concentration infusion of propofol and tracheal intubation on QTc interval.
MedLine Citation:
PMID:  18717665     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the effect of target controlled infusion of propofol on QTc interval and tracheal intubation. Twenty-five unpremedicated, ASA class I or II patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. The QTc interval was measured before anaesthetic induction (baseline, T1), 10 min after propofol infusion (T2), immediately after tracheal intubation (T3), and 1 min after tracheal intubation (T4). The QTc interval increased significantly at 10 min after the propofol infusion started compared to baseline (p = 0.003). After tracheal intubation, the QTc interval was further increased when compared to that at T2 (p < 0.0001). The increased QTc interval was within normal limit and no patient had an arrhythmia. In conclusion, although statistically significant, the increase in QTc interval was too small to be clinically significant during propofol infusion. However, the combination of propofol and tracheal intubation must be used carefully in patients with prolonged QTc interval.
D H Kim; T D Kweon; S B Nam; D W Han; W Y Cho; J S Lee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-20
Journal Detail:
Title:  Anaesthesia     Volume:  63     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1061-4     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Anesthetics, Intravenous / administration & dosage,  adverse effects*
Blood Pressure / drug effects
Heart Rate / drug effects
Infusions, Intravenous
Intubation, Intratracheal / adverse effects*
Long QT Syndrome / chemically induced,  etiology*
Middle Aged
Monitoring, Intraoperative / methods
Propofol / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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