| Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease. | |
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MedLine Citation:
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PMID: 18481025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza BUNGE which exerts antioxidant and anti-inflammatory actions in many experimental disease models. In the present study, we demonstrated that the standardized fraction of S. miltiorrhiza (Sm-SF) was able to protect RAW 264.7 cells from ethanol-and lipopolysaccharide (LPS)-induced production of superoxide radical, activation of NADPH oxidase and subsequently death of the cells. Among four main components of Sm-SF, tanshinone IIA was the most potent in protecting cells from LPS-and ethanol-induced cytotoxicity. LPS or ethanol induced the expression of CD14, iNOS, and SCD1 and decreased RXR-alpha, which was completely reversed by tanshinone IIA. In H4IIEC3 cells, 10 microM tanshinone IIA effectively blocked ethanol-induced fat accumulation as evidenced by Nile Red binding assay. These results indicate that tanshinone IIA may have potential to inhibit alcoholic liver disease by reducing LPS-and ethanol-induced Kupffer cell sensitization, inhibiting synthesis of reactive oxygen/nitrogen species, inhibiting fatty acid synthesis and stimulating fatty acid oxidation. |
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Authors:
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Hu-Quan Yin; Youn-Su Kim; You-Jin Choi; Youn-Chul Kim; Dong-Hwan Sohn; Shi-Yong Ryu; Byung-Hoon Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-15 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 31 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-15 Completed Date: 2008-08-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 659-65 Citation Subset: IM |
Affiliation:
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College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death / drug effects Cell Line, Tumor Cells, Cultured Cytoprotection Drugs, Chinese Herbal / pharmacology* Ethanol / pharmacology* Gene Expression Profiling Hepatocytes / cytology, drug effects*, metabolism Lipid Metabolism Lipopolysaccharides / pharmacology* Liver Diseases, Alcoholic / metabolism Mice Phenanthrenes / pharmacology* Plant Extracts / pharmacology* Rats Reactive Oxygen Species / metabolism Salvia miltiorrhiza* |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Lipopolysaccharides; 0/Phenanthrenes; 0/Plant Extracts; 0/Reactive Oxygen Species; 568-73-0/tanshinone; 64-17-5/Ethanol |
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