Document Detail


Effects of tamsulosin on lower urinary tract symptoms due to double-J stent: a prospective study.
MedLine Citation:
PMID:  19641362     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of tamsulosin in improving symptoms in, and quality of life of, patients with indwelling double-J ureteral stents. PATIENTS AND METHODS: This prospective study lasted from January 2005 to February 2007. All the patients with symptomatic lower ureteral stones with <15 mm diameter were enrolled in this prospective study, and were prospectively randomized (programs Plus 1.0 and Plus 2.10; S-Plus, Taiwan) into two groups. There was a total of 146 patients with insertion of a double-J ureteral stent after ureteroscopic stone removal. In group 1, 71 patients were enrolled and they received placebo for 2 weeks. Group 2 included 75 patients who received 0.4 mg of tamsulosin, once daily for 2 weeks. All patients completed a 10-cm linear visual analogue scale (VAS) for evaluating pain and voiding flank pain, and irritative domain of the International Prostate Symptom Scale (IPSS) before double-J stent removal 2 weeks later. RESULTS: The mean VAS for pain was 4.01 in group 1, 1.52 in group 2, and for voiding flank pain it was 3.3 in group 1 and 1.93 in group 2. The mean score of frequency in IPSS was 3.7 in group 1 and 1.55 in group 2. The mean score of urgency in IPSS was 3.82 in group 1 and 1.43 in group 2. The mean score of nocturia in IPSS was 2.01 in group 1 and 0.65 in group 2. The mean score of quality of life in IPSS was 4.21 in group 1 and 1.6 in group 2. All p values are <0.0001 with statistical significances. CONCLUSIONS: Tamsulosin improved a subset of stent-related urinary symptoms, pain, voiding flank pain and quality of life.
Authors:
Chung-Jing Wang; Shi-Wei Huang; Chien-Hsing Chang
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-07-27
Journal Detail:
Title:  Urologia internationalis     Volume:  83     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-30     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Division of Urology, Department of Surgery, Saint Martin De Porres Hospital, Chiayi, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / therapeutic use*
Adult
Aged
Female
Flank Pain / drug therapy,  etiology
Humans
Male
Middle Aged
Quality of Life
Stents / adverse effects*
Sulfonamides / therapeutic use*
Ureter*
Ureteral Calculi / surgery
Urination Disorders / drug therapy*,  etiology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Sulfonamides; 106133-20-4/tamsulosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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