Document Detail


Effects of tamsulosin on hypogastric nerve stimulation-induced intraurethral pressure elevation in male and female dogs under anesthesia.
MedLine Citation:
PMID:  15336951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate the effects of tamsulosin, an alpha(1)-adrenoceptor antagonist, on hypogastric nerve stimulation-induced intraurethral pressure elevation in anesthetized male and female dogs and to evaluate sex differences in these effects. Additionally, the effects of tamsulosin were also compared with those of other alpha(1)-adrenoceptor antagonists, namely prazosin, naftopidil and urapidil. Tamsulosin dose-dependently inhibited hypogastric nerve stimulation-induced intraurethral pressure elevation, with doses required to induce 50% inhibition of the elevation (ED(50) values) of 0.72 and 0.74 microg/kg i.v. in anesthetized male and female dogs, respectively. Mean arterial blood pressure slightly decreased after administration of tamsulosin at a dose which inhibited intraurethral pressure elevation almost completely. Prazosin, naftopidil and urapidil also inhibited increases in intraurethral pressure in a dose-dependent fashion, but caused decreases in mean arterial blood pressure at the same doses. The estimated rank order of inhibitory potency for urethral response was tamsulosin>prazosin>naftopidil=urapidil. In conclusion, tamsulosin dose-dependently inhibited increases in intraurethral pressure with little effect on mean arterial blood pressure in both male and female dogs, and these effects were almost equipotent. These results indicate that tamsulosin will be useful in the treatment of dysuria associated with lower urinary tract symptoms in women as well as men.
Authors:
Akiyoshi Ohtake; Shuichi Sato; Chikashi Saitoh; Hironori Yuyama; Masao Sasamata; Keiji Miyata
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  497     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2005-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
Affiliation:
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. ohtake@yamanouchi.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Female
Hypogastric Plexus / drug effects*,  physiology
Male
Naphthalenes / pharmacology
Piperazines / pharmacology
Prazosin / pharmacology
Pressure
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors*
Sex Factors
Sulfonamides / pharmacology*
Urethra / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Naphthalenes; 0/Piperazines; 0/Receptors, Adrenergic, alpha-1; 0/Sulfonamides; 106133-20-4/tamsulosin; 19216-56-9/Prazosin; 34661-75-1/urapidil; 57149-07-2/naftopidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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