Document Detail


Effects of tacrine upon murine neuroblastoma cells.
MedLine Citation:
PMID:  8748676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tacrine [9-amino-1,2,3,4-tetrahydroacridine] (THA), a potent acetylcholinesterasic inhibitor, is utilized in the pharmacological treatment of Alzheimer's disease (Birne and Arie, 1994). Cytopharmacology of THA is still largely to be discovered. In the present paper we report some effects produced by THA on murine neuroblastoma cells (N2A) used as an experimental model. N2A cells treated with THA at low concentration (1 mu M) showed a reduced cell's mitosis and a remarkable reduction of protein synthesis. Eventually, a marked reduction on the phosphorylation of proteins associated to neurofilaments 200 kD, is observed using specific antibody.
Authors:
P Zatta; P Zambenedetti; M B Marturano; M Palumbo; M Nicolini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  102     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1995  
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  113-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy
Animals
Mice
Microscopy, Electron, Scanning
Mitosis / drug effects
Neuroblastoma / drug therapy*
Neurofilament Proteins / drug effects
Phosphorylation / drug effects
Tacrine / pharmacology*
Chemical
Reg. No./Substance:
0/Neurofilament Proteins; 4VX7YNB537/Tacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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