Document Detail

Effects of systemically applied clonidine on intestinal perfusion and oxygenation in healthy pigs during general anaesthesia and laparotomy.
MedLine Citation:
PMID:  16225726     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Clonidine, which is used for induction of sympatholysis and prevention or treatment of alcohol withdrawal in anaesthesia and intensive care medicine, may have deleterious effects on intestinal mucosal perfusion. This study was designed to investigate the effects of clonidine on intestinal perfusion and oxygenation. METHODS: Following ethical approval 17 anaesthetized, and acutely instrumented pigs were randomly assigned to two groups: eight animals received intravenous clonidine (2 microg kg(-1) bolus and 2 microg kg(-1) h(-1)), nine animals served as a control group. Measurement points for systemic and regional haemodynamic and oxygenation parameters were 135 and 315 min after starting the clonidine application. RESULTS: Clonidine elicited systemic haemodynamic changes (median [25-75th interquartile range]): heart rate (106 [91, 126] to 84 [71, 90] beats min(-1)) cardiac output (147 [123, 193] to 90 [87, 107] mL min(-1) kg(-1)) and mean arterial pressure (77 [72, 93] to 69 [61, 78] mmHg) decreased. Despite systemic haemodynamic changes, the superior mesenteric artery blood flow did not change in the clonidine group. The vascular resistance of the superior mesenteric artery decreased. The small intestinal oxygen supply, the mucosal and the serosal tissue oxygen partial pressure did not change. CONCLUSIONS: Systemic sympatholysis induced by intravenously applied clonidine in addition to basic intravenous anaesthesia elicited a decrease in cardiac output and mean arterial pressure. However, regional macrohaemodynamic perfusion was maintained and intestinal oxygenation did not change. Clonidine does not impair intestinal mucosal and serosal oxygenation under physiological conditions.
D A Vagts; T Iber; J P Roesner; C Mutz; V Kurzweg; C Harkner; K Brüderlein; G F E Nöldge-Schomburg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  22     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-01-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  879-86     Citation Subset:  IM    
Universität Rostock, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Rostock, Germany.
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MeSH Terms
Anesthesia, General*
Clonidine / administration & dosage,  adverse effects*
Hemodynamics / drug effects
Intestinal Mucosa / blood supply,  drug effects,  metabolism
Intestine, Small* / blood supply,  drug effects,  metabolism
Oxygen / metabolism*
Splanchnic Circulation / drug effects
Sus scrofa
Sympatholytics / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Sympatholytics; 4205-90-7/Clonidine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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