Document Detail

Effects of systemic hypothermia on myocardial metabolism and coronary blood flow in the fibrillating heart.
MedLine Citation:
PMID:  439925     Owner:  NLM     Status:  MEDLINE    
Ventricular fibrillation during normothermic cardiopulmonary bypass is deleterious to the myocardium. This study was undertaken to determine if moderate systemic hypothermia would protect the myocardium during ventricular fibrillation. Fourteen mongrel dogs were subjected to 1 hour, 15 minutes of total cardiopulmonary bypass. Ventricular fibrillation was induced by a continuous electrical alternating current applied at the beginning of bypass and lasting for 1 hour. Six animals were maintained at normothermia (Group I), and eight were cooled to 30 degrees C. for 1 hour (Group II). The hypothermic group (Group II) demonstrated lower myocardial oxygen consumption and metabolism, decreased coronary blood flow, and less myocardial lactate production during ventricular fibrillation than did Group I. It is concluded that hypothermia does offer some protection, although not complete, against the deleterious effects of ventricular fibrillation described previously.
J F Vinas; J G Fewel; K V Arom; J K Trinkle; F L Grover
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  77     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  900-7     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Blood Pressure
Cardiac Output
Cardiomyopathies / etiology*,  prevention & control
Coronary Circulation*
Evaluation Studies as Topic
Hypothermia, Induced*
Lactates / metabolism
Myocardium / metabolism*
Oxygen Consumption
Ventricular Fibrillation / metabolism,  physiopathology*
Reg. No./Substance:
0/Lactates; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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