Document Detail

Effects of a synthetic lung surfactant on pharyngeal patency in awake human subjects.
MedLine Citation:
PMID:  9029201     Owner:  NLM     Status:  MEDLINE    
We examined the effects of separate applications of saline and a synthetic lung surfactant preparation (Surf; Exosurf Neonatal) into the supraglottic airway (SA) on the anteroposterior pharyngeal diameter (Dap) and the airway pressures required to close (Pcl) and reopen (Pop) the SA in five awake normal supine subjects. Dap, Pcl, and P(op) were determined during lateral X-ray fluoroscopy and voluntary glottic closure when pressure applied to the SA lumen was decreased from 0 to -20 cmH2O and then increased to +20 cmH2O. After Surf application and relative to control, Dap was larger for most of the applied pressures, Pcl decreased (-12.3 +/- 1.9 to -18.7 +/- 0.9 cmH2O; P < 0.01), P(op) decreased (13.4 +/- 1.9 to -6.0 +/- 3.4 cmH2O; P < 0.01), and genioglossus electromyographic activity did not change (P > 0.05). Saline had no effect. These observations suggest that pharyngeal intraluminal surface properties are important in maintaining pharyngeal patency. We propose that surfactants enhance pharyngeal patency by reducing surface tension and adhesive forces acting on intraluminal SA surfaces.
T Van der Touw; A B Crawford; J R Wheatley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  82     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-28     Completed Date:  1997-04-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  78-85     Citation Subset:  IM    
Department of Respiratory Medicine, Westmead Hospital, New South Wales, Australia.
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MeSH Terms
Pharynx / drug effects*,  physiology*
Pulmonary Surfactants / pharmacology*
Respiratory Physiological Phenomena*
Respiratory System / drug effects*
Wakefulness / physiology*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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