Document Detail


Effects of synthetic kassinin on splanchnic circulation and exocrine pancreas in dogs.
MedLine Citation:
PMID:  3244558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of intravenously administered synthetic kassinin on splanchnic circulation and exocrine pancreatic secretion were examined in six anesthetized dogs. Kassinin caused dose-related increases in the blood flow in superior mesenteric artery and portal vein, and produced an initial increase followed by a decrease in pancreatic blood flow, but did not affect the exocrine pancreatic secretion. This study demonstrates that kassinin affects splanchnic blood flow in dogs, and suggests that kassinin or a kassinin-like substance functions as a neuropeptide controlling the splanchnic circulation in mammalian species.
Authors:
R Doi; K Inoue; M Kogire; S Sumi; K Takaori; M Yun; H Yajima; T Tobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  9     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1988 Sep-Oct
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1055-8     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Female
Kassinin / pharmacology*
Male
Pancreas / blood supply,  drug effects,  secretion*
Pancreatic Juice / drug effects,  secretion*
Reference Values
Regional Blood Flow / drug effects
Secretin / pharmacology
Splanchnic Circulation / drug effects*
Chemical
Reg. No./Substance:
1393-25-5/Secretin; 63968-82-1/Kassinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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