Document Detail


Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs.
MedLine Citation:
PMID:  1717953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions.
Authors:
R Doi; K Inoue; R Hosotani; S Higashide; K Takaori; S Funakoshi; H Yajima; P L Rayford; T Tobe
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amylases / secretion
Animals
Cholecystokinin / pharmacology
Dogs
Humans
Male
Pancreas / blood supply,  drug effects*,  secretion
Pancreatic Hormones / pharmacology*
Peptide Fragments / pharmacology*
Proteins / secretion
Rats
Rats, Inbred Strains
Recombinant Proteins / pharmacology
Regional Blood Flow / drug effects
Grant Support
ID/Acronym/Agency:
DK30415-08/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Pancreatic Hormones; 0/Peptide Fragments; 0/Proteins; 0/Recombinant Proteins; 111364-77-3/pancreastatin-52; 113817-19-9/pancreastatin-29; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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