Document Detail

Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs.
MedLine Citation:
PMID:  1717953     Owner:  NLM     Status:  MEDLINE    
Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions.
R Doi; K Inoue; R Hosotani; S Higashide; K Takaori; S Funakoshi; H Yajima; P L Rayford; T Tobe
Related Documents :
1004013 - Regional blood flow to the lymph node during the immune response.
23886893 - Neurodevelopment after fetal growth restriction.
119053 - Alteration in the distribution of organ perfusion following profound hypothermia and ci...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amylases / secretion
Cholecystokinin / pharmacology
Pancreas / blood supply,  drug effects*,  secretion
Pancreatic Hormones / pharmacology*
Peptide Fragments / pharmacology*
Proteins / secretion
Rats, Inbred Strains
Recombinant Proteins / pharmacology
Regional Blood Flow / drug effects
Grant Support
Reg. No./Substance:
0/Pancreatic Hormones; 0/Peptide Fragments; 0/Proteins; 0/Recombinant Proteins; 111364-77-3/pancreastatin-52; 113817-19-9/pancreastatin-29; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of potent bombesin antagonist on exocrine pancreatic secretion in rats.
Next Document:  Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion.