| Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs. | |
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MedLine Citation:
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PMID: 1717953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions. |
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Authors:
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R Doi; K Inoue; R Hosotani; S Higashide; K Takaori; S Funakoshi; H Yajima; P L Rayford; T Tobe |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 12 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1991 May-Jun |
Date Detail:
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Created Date: 1991-10-31 Completed Date: 1991-10-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-502 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Kyoto University Faculty of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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secretion Animals Cholecystokinin / pharmacology Dogs Humans Male Pancreas / blood supply, drug effects*, secretion Pancreatic Hormones / pharmacology* Peptide Fragments / pharmacology* Proteins / secretion Rats Rats, Inbred Strains Recombinant Proteins / pharmacology Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK30415-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pancreatic Hormones; 0/Peptide Fragments; 0/Proteins; 0/Recombinant Proteins; 111364-77-3/pancreastatin-52; 113817-19-9/pancreastatin-29; 9011-97-6/Cholecystokinin; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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