| Effects of synthesized phosphodiesterase inhibitors, DM 9278 and HWA 285, on pancreatic exocrine secretion of the dog. | |
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MedLine Citation:
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PMID: 3841375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of synthesized phosphodiesterase inhibitors, DM 9278 and HWA 285, on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas. Close-arterial injections of DM 9278 (10-300 micrograms) and HWA 285 (300-3000 micrograms) caused dose-dependent increases in the flow rate of pancreatic juice and perfusion blood flow. Bicarbonate concentration in the pancreatic juice stimulated by DM 9278 (300 micrograms) or HWA 285 (3000 micrograms) was significantly higher than that in the resting pancreatic juice, although neither of the compounds affected protein concentrations in the pancreatic juice. In the secretory volume, 100 micrograms of DM 9278 corresponded roughly to 1000 micrograms of HWA 285, 0.1 units of secretin or 0.3 units of pancreozymin. These secretory and vascular effects were not modified by pretreatment with atropine or sulpiride. This study suggests that both DM 9278 and HWA 285 act directly on ductular cells of the pancreas and induce secretion of water and electrolytes. |
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Authors:
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F Yamagishi; N Homma; K Haruta; K Iwatsuki; S Chiba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 39 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1986-03-21 Completed Date: 1986-03-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Cholecystokinin / pharmacology Dogs Female Male Pancreas / blood supply, secretion* Pancreatic Juice / secretion Phosphodiesterase Inhibitors / pharmacology* Proteins / metabolism Quinazolines / pharmacology* Regional Blood Flow / drug effects Secretin / pharmacology Sulpiride / pharmacology Xanthines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Phosphodiesterase Inhibitors; 0/Proteins; 0/Quinazolines; 0/Xanthines; 1393-25-5/Secretin; 15676-16-1/Sulpiride; 51-55-8/Atropine; 55242-55-2/propentofylline; 9011-97-6/Cholecystokinin; 91599-59-6/DM 9278 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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