| Effects of switching to SofZia-preserved travoprost in patients who presented with superficial punctate keratopathy while under treatment with latanoprost. | |
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MedLine Citation:
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PMID: 20151269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the effects of switching to SofZia-preserved travoprost (TRV) on superficial punctate keratopathy (SPK) observed in patients using benzalkonium chloride (BAC)-preserved latanoprost (LAT). METHODS: Patients with either primary open-angle glaucoma or ocular hypertension treated with LAT for at least 1 month who presented with SPK participated in this prospective, multicenter, open-label uncontrolled study. After the switch from LAT to TRV, patients were monitored at 2 weeks and at 1, 2, and 3 months. The use of concomitantly employed ophthalmic solutions was continued during the observation period. The intensity of SPK in each of five areas defined on the cornea was scored on a standard scale. Repeated measurements were tested with a linear mixed model. RESULTS: Of the 48 patients enrolled, 45 patients completed the study. After the switch to TRV, the mean SPK score in the whole cornea decreased significantly at every observation point (P < 0.0001 at each point) while intraocular pressure did not change significantly. Throughout the observation period, the SPK score tended to be higher in patients using a larger number of concomitant medications that contained BAC. CONCLUSION: Switching to TRV improved SPK observed in a population using LAT, likely because of a decrease in exposure to BAC. |
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Authors:
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Sei Yamazaki; Mami Nanno; Tairo Kimura; Hirotaka Suzumura; Keiji Yoshikawa |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study Date: 2010-02-12 |
Journal Detail:
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Title: Japanese journal of ophthalmology Volume: 54 ISSN: 1613-2246 ISO Abbreviation: Jpn. J. Ophthalmol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: Japan |
Other Details:
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Languages: eng Pagination: 7-14 Citation Subset: IM |
Affiliation:
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Yamazaki Eye Clinic, Tokyo, Japan. yamazakisei@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antihypertensive Agents / therapeutic use* Benzalkonium Compounds / adverse effects Cloprostenol / analogs & derivatives*, therapeutic use Corneal Diseases / chemically induced, drug therapy* Female Fluorophotometry Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure / drug effects Male Middle Aged Ocular Hypertension / drug therapy Preservatives, Pharmaceutical / adverse effects, therapeutic use* Prospective Studies Prostaglandins F, Synthetic / therapeutic use Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzalkonium Compounds; 0/Preservatives, Pharmaceutical; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost; 157283-68-6/travoprost; 40665-92-7/Cloprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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