Document Detail

Effects of switching from Depakene to generic valproic acid on individuals with mental retardation.
MedLine Citation:
PMID:  9425876     Owner:  NLM     Status:  MEDLINE    
In an 8-week open-trial substitution study, 64 subjects with seizure disorders living at an ICF/MR were randomly assigned to either brand-named Depakene or generic Valproic Acid USP (Solvay) medication. After 4 weeks, they were switched to the other medication. Blood levels and seizures were monitored. The price of the generic Valproic Acid was less than one tenth the price of Depakene. Results show that subjects had no statistically significant changes in seizures or blood levels when the two treatment regimens were compared. These findings suggest that generic Valproic Acid USP (Solvay) may be successfully used in this population, resulting in substantial cost savings.
V J Vadney; K W Kraushaar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mental retardation     Volume:  35     ISSN:  0047-6765     ISO Abbreviation:  Ment Retard     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  18640670R     Medline TA:  Ment Retard     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-72     Citation Subset:  IM    
Abilene State School, Texas Department of Mental Health and Mental Retardation 79604, USA.
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MeSH Terms
Anticonvulsants / therapeutic use*
Cross-Over Studies
Drugs, Generic*
Mental Retardation / complications*
Middle Aged
Seizures / complications*,  drug therapy*
Valproic Acid / therapeutic use*
Reg. No./Substance:
0/Anticonvulsants; 0/Drugs, Generic; 99-66-1/Valproic Acid
Comment In:
Ment Retard. 1998 Aug;36(4):330-1   [PMID:  9713191 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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